Retatrutide yog ib qho tshiab hluavtaws peptide uas tau tsim los rau tib lub sijhawm qhib peb lub receptors tseem ceeb koom nrog hauv qabzib homeostasis thiab lub zog sib npaug: glucagon receptor (GCGR), glucose-dependent insulinotropic polypeptide receptor (GIPR) thiab glucagon-zoo li peptide-1 receptor (GLP- 1R) (Finan et al., 2023, New England Journal of Medicine).Los ntawm kev tsom mus rau cov receptors no, rettrutide ua raws li cov teebmeem ntawm lawv cov ligands endogenous, glucagon, GIP thiab GLP-1, uas yog cov tshuaj hormones uas tswj cov piam thaj metabolism thiab lub cev hnyav hauv ntau cov ntaub so ntswg, xws li pancreas, siab, hlwb, cov ntaub so ntswg adipose thiab plab hnyuv. tract (Drucker, 2023, Xwm).
Tsis zoo li cov ligands endogenous, uas muaj ib nrab-lub neej luv luv, sai degradation los ntawm dipeptidyl peptidase-4 (DPP-4) enzyme thiab undesirable phiv, xws li hypoglycemia thiab xeev siab (Drucker, 2023, Xwm), retatrutide tau engineered los kov yeej cov no. txwv.Retatrutide yog ib qho fusion peptide tsim los ntawm kev hloov kho glucagon txuas mus rau qhov hloov kho GLP-1 ntu ntawm GIP ib ntus (Finan li al., 2023, New England Journal of Medicine).Cov kev hloov kho muaj xws li amino acid hloov pauv thiab tshem tawm uas txhim kho kev ruaj ntseg, muaj zog thiab kev xaiv ntawm peptide rau peb lub receptors (Finan li al., 2023, The New England Journal of Medicine).
Retatrutide tau qhia txog cov tshuaj muaj txiaj ntsig zoo thiab kho tau zoo hauv kev rog rog thiab ntshav qab zib hom 2 hauv kev tshawb fawb txog kev kho mob thiab kho mob.Hauv cov tsiaj ua qauv ntawm kev rog thiab ntshav qab zib, rettrutide tau pom tias muaj txiaj ntsig zoo ntawm kev txo qis cov ntshav qabzib, txhawb kev tsim cov tshuaj insulin, txo qis glucagon secretion, ua rau lub plab zom mov, txo cov khoom noj thiab lub cev hnyav piv rau ib leeg lossis ob lub agonists ntawm peb receptors (Gault et al., 2023, Ntshav Qab Zib, Obesity thiab Metabolism; Coskun et al., 2023a, Molecular Metabolism).Retatrutide kuj tau txhim kho lipid profile, lub siab ua haujlwm, mob thiab cov hlab plawv tsis zoo hauv cov tsiaj no (Gault li al., 2023, Ntshav qab zib, rog rog thiab Metabolism; Coskun li al., 2023a, Molecular Metabolism).
Hauv tib neeg kev sim tshuaj, rettrutide kuj tau pom cov txiaj ntsig tau zoo hauv cov neeg mob rog thiab ntshav qab zib.Retatrutide tau txais txiaj ntsig zoo thiab pom tias muaj kev cuam tshuam ntawm koob tshuaj ntawm kev txo cov ntshav qabzib, txhawb kev tsim cov tshuaj insulin, txo qis glucagon secretion thiab txo qis qab los noj mov hauv theem 1 kev tshawb fawb nrog cov neeg ua haujlwm noj qab haus huv thiab cov neeg mob ntshav qab zib hom 2 (Coskun li al., 2023b, Diabetes Care. ).Retatrutide ua tiav txog li 17.5% txhais tau tias qhov hnyav txo ntawm 24 lub lis piam piv rau cov placebo hauv kev tshawb fawb theem 2 uas cuam tshuam nrog cov neeg mob rog thiab rog.Qhov kev poob phaus no tau nrog kev txhim kho hauv kev tswj glycemic, lipid profile, lub siab ua haujlwm thiab lub neej zoo (Lilly's theem 2 rettrutide cov txiaj ntsig tau luam tawm nyob rau hauv New England Journal of Medicine qhia qhov kev tshawb nrhiav molecule tau nce mus txog 17.5% txhais tau tias qhov hnyav txo ntawm 24 lub lis piam hauv Cov neeg laus uas rog rog thiab rog rog., 2023).Retatrutide kuj tseem muaj cov ntaub ntawv muaj txiaj ntsig zoo uas tsis muaj cov xwm txheej tsis zoo lossis qhov tshwm sim ntawm cov ntshav qabzib ntau.
Daim duab 1. Retatrutide (LY3437943) inhibits glycated hemoglobin A1c (HbA1c) tus nqi (A) thiab lub cev hnyav (B) dhau sijhawm.
(Urva S, Coskun T, Loh MT, Du Y, Thomas MK, Gurbuz S, Haupt A, Benson CT, Hernandez-Illas M, D'Alessio DA, Milicevic Z. LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist hauv cov neeg mob ntshav qab zib hom 2: theem 1b, multicentre, ob-dig muag, placebo-tswj, randomised, ntau-ascending dose sim. Lancet. 2022 Nov 26; 400(10366):1869-1881.)
Retatrutide yog tam sim no nyob rau hauv kev txhim kho los ntawm Eli Lilly thiab Tuam Txhab raws li tus neeg sib tw tshuaj tshiab rau kev rog thiab ntshav qab zib hom 2.Nws sawv cev rau txoj hauv kev tshiab rau lub hom phiaj ntau yam receptors koom nrog hauv cov piam thaj metabolism thiab lub zog sib npaug nrog ib qho molecule.Retatrutide tau pom tias muaj txiaj ntsig zoo tshaj plaws hauv cov qauv tsiaj thiab kev sim tib neeg nrog kev nyab xeeb zoo thiab kev ua haujlwm ntev.Cov kev tshawb fawb ntxiv yog xav tau kom paub meej tias nws cov txiaj ntsig mus sij hawm ntev thiab muaj peev xwm txaus ntshai hauv cov neeg coob thiab ntau haiv neeg.Retatrutide tuaj yeem muab cov kev xaiv tshiab rau cov neeg mob uas tawm tsam kev rog thiab ntshav qab zib thiab xav tau kev kho mob zoo dua.
Peb yog cov chaw tsim khoom polypeptide hauv Suav teb, nrog ntau xyoo ntawm kev paub tab hauv kev tsim cov polypeptide.Hangzhou Taijia Biotech Co., Ltd. yog lub chaw tsim khoom ntawm polypeptide raw khoom, uas tuaj yeem muab tau kaum tawm txhiab tus polypeptide raw cov ntaub ntawv thiab tuaj yeem kho raws li kev xav tau.Qhov zoo ntawm cov khoom polypeptide yog qhov zoo heev, thiab qhov purity tuaj yeem ncav cuag 98%, uas tau lees paub los ntawm cov neeg siv thoob plaws ntiaj teb. Zoo siab txais tos los tham nrog peb.
