Kab mob plawv, uas yog qhov ua rau tuag ntawm cov kab mob tsis sib kis, feem ntau yog kab mob uas muaj feem cuam tshuam txog kev laus.Nrog rau lub hnub nyoog nce, lub plawv, raws li cov ntshav siv lub cev, yuav muaj hnub nyoog, thiab nws lub peev xwm los so thiab kev cog lus yuav poob qis, thiab nws yuav maj mam nqus tsis tau cov ntshav mus rau tag nrho lub cev, uas yuav ua rau lub plawv tsis ua haujlwm. cov neeg mob thiab cuam tshuam rau tib neeg lub neej noj qab haus huv.
Kev laus ntawm lub plawv yog tus cwj pwm los ntawm kev txo qis ntawm lub plawv contractility (lub plawv muaj nuj nqi), uas yuav tau nrog kev txo qis ntawm cov protein ntau thiab cov kev hloov pauv ntawm cov protein tom qab kev hloov pauv.
SS-31 peptide yog cardiolipin peroxidase inhibitor thiab mitochondrial targeting peptide.Nws tuaj yeem txhim kho txoj haujlwm ntawm sab laug ventricle thiab mitochondria.SS-31 peptide tuaj yeem txo qis mitochondrial tsis ua haujlwm thiab oxidative puas tsuaj hauv tib neeg cov kab mob meshwork hlwb.Nws tuaj yeem tiv thaiv iHTM thiab GTM (3) hlwb los ntawm kev txhawb nqa oxidative kev nyuaj siab los ntawm H2O2.
SS-31 yog mitochondrial lub hom phiaj los tiv thaiv kev laus, uas tau raug pov thawj tias muaj txiaj ntsig zoo hauv kev rov ua haujlwm ntawm lub plawv ntawm cov nas muaj hnub nyoog.Nws yog ib qho hluavtaws tetrapeptide ua ke nrog mitochondrial puab daim nyias nyias, uas tuaj yeem txhim kho mitochondrial muaj nuj nqi, txo cov kev tsim cov pa oxygen reactive ROS, txo cov theem ntawm cov pro-inflammatory yam tseem ceeb thiab feem ntau txhim khu lub diastolic muaj nuj nqi ntawm lub plawv.
Ua ntej, muab piv rau cov nas me nrog cov nas qub, cov kws tshawb fawb pom tias qhov muaj ntau ntawm mitochondrial proteins tshwj xeeb yog cuam tshuam los ntawm kev laus, suav nrog mitochondrial signal transduction txoj kev, cov proteins uas cuam tshuam rau oxidative phosphorylation txoj hauv kev uas ua rau lub zog, thiab cov proteins muaj feem xyuam rau SIRT teeb liab transduction txoj kev muaj feem xyuam rau lub zog. metabolism hauv mitochondria.Tsis tas li ntawd, cov proteins tseem ceeb troponin thiab tropomyosin, uas ncaj qha kho myocardial contraction, kuj pom tseeb cuam tshuam los ntawm kev laus.Cov no muaj feem cuam tshuam nrog kev ua haujlwm plawv.Qhov thib ob, thaum xav txog kev cuam tshuam ntawm SS-31 kev kho mob, cov kws tshawb fawb pom tias cov protein ntau ntawm cov nas qub uas kho tsis tau zoo li cov pab pawg hluas, tab sis lawv txhua tus tau pom qhov rov qab los ntawm txoj kev tsis ua haujlwm nrog kev laus, xws li cov protein ntau ntawm lub voj voog tricarboxylic acid, txoj hauv kev tseem ceeb ntawm kev tsim hluav taws xob hauv lub cev, uas tau rov zoo los ntawm qhov zoo, ua rau cov nas qub qub.Qhov no txhais tau hais tias SS-31 yog qhov tshwj xeeb tshaj yog rau kev hloov pauv ntawm lub zog metabolism los ntawm lub plawv aging.Kev tshawb nrhiav cov protein ntau tau los txog qhov kawg, thiab tom qab ntawd cov kws tshawb fawb tau tig lawv lub ntsej muag rau cov kev hloov pauv ntawm cov protein tom qab kev hloov pauv hloov thaum lub sij hawm kev laus, thiab tshwj xeeb tshaj yog xaiv cov kev hloov pauv tom qab kev hloov pauv hauv cov protein, uas feem ntau cuam tshuam rau lub plawv. - Kev hloov kho acetylation.Tej zaum yuav muaj ob qhov kev hloov pauv hauv acetylation.Ua ntej, vim hais tias cov acetylation ntawm mitochondrial protein yuav nce nrog lub hnub nyoog, ua rau mitochondrial tsis ua hauj lwm, thiab cov ntsiab lus mitochondrial ntawm lub plawv yog siab heev, yog li tag nrho lub plawv yuav muaj acetylation tsub zuj zuj thaum lub plawv ua hauj lwm poob;Qhov thib ob, yuav muaj qhov poob ntawm ib txwm acetylation ntawm cov khoom seem hauv cov txheej txheem kev laus, uas yuav ua rau tsis ua haujlwm ntawm nws txoj haujlwm.Cov kws tshawb fawb tau txhawb cov acetylated peptides hauv lub plawv (uas tuaj yeem nkag siab yooj yim raws li cov khoom me me siv los tsim cov protein).Tseem muaj qhov sib txawv ntawm cov txheej txheem acetylation ntawm lub plawv cov protein ntawm cov tub ntxhais hluas thiab pab pawg qub, tab sis nws tsis pom tseeb li cov protein ntau.Tom qab ntawd lawv kuj tau tshawb nrhiav ntxiv uas cov proteins qhov kev hloov pauv hauv acetylation tuaj yeem yog qhov tshwj xeeb rau.Thaum kawg, cov kws tshawb nrhiav ib zaug ntxiv txuas lub peev xwm systolic thiab diastolic ntawm lub plawv thiab pom 14 qhov chaw acetylation cuam tshuam nrog lub peev xwm diastolic ntawm lub plawv, thiab tag nrho cov ntawm lawv tau cuam tshuam tsis zoo.Nyob rau tib lub sijhawm, ob qhov chaw ntsig txog kev mob plawv kuj tau pom.Qhov no txhais tau hais tias kev hloov pauv ntawm kev cog lus thaum lub sijhawm laus tuaj yeem tswj hwm los ntawm lub xeev acetylation ntawm lub plawv protein.
Peb yog cov chaw tsim khoom polypeptide hauv Suav teb, nrog ntau xyoo ntawm kev paub tab hauv kev tsim cov polypeptide.Hangzhou Taijia Biotech Co., Ltd. yog lub chaw tsim khoom ntawm polypeptide raw khoom, uas tuaj yeem muab tau kaum tawm txhiab tus polypeptide raw cov ntaub ntawv thiab tuaj yeem kho raws li kev xav tau.Qhov zoo ntawm cov khoom polypeptide yog qhov zoo heev, thiab qhov purity tuaj yeem ncav cuag 98%, uas tau lees paub los ntawm cov neeg siv thoob plaws ntiaj teb. Zoo siab txais tos los tham nrog peb.
